Lower tolerance for mediocrity: few chances, not nine
Hormozi frames raising the bar as lowering tolerance for mediocre work: don't give nine chances to mediocre performers — give a few, and then that's it.
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Hormozi frames raising the bar as lowering tolerance for mediocre work: don't give nine chances to mediocre performers — give a few, and then that's it.
Quigley recommends building an organizational culture and frictionless tooling that tracks batch effects and metadata for every experiment, so lab artifacts and 'cheating modes' can be chased down. He also recommends going back and auditing all historical experimental data against the company's founding history to verify results are consistent, and when you see big changes, identifying and mitigating what drove them. Screening data is full of accidental 'cheating modes' that emerge as consequences of doing laboratory work — his team has made many mistakes bumping into them — and without a team that has a nose for these experimental mistakes, replicating the platform will take a long time. When replicating DEL screens, pay constant attention to everything that can go sideways, because autom
None significant.
Harish Gaggar advises that every high-risk action item should retain an always-on human-in-the-loop process, because removing the human from the loop risks unreviewed consequential agent actions.
When you configure AI tooling access, it should inherit the same identity provider enforcement as human access. A finance user's identity should never be able to grant an assistant permission to answer things like how to get around internal data loss prevention measures.
Deploy a model proxy layer that sits between the model and the agent to inspect, filter, and log every call going between them. Such a layer could have flagged a request like 'hey, how do I bypass DLP' before it actually got answered, and could strip injected instructions out of external content before the agent reads it.
Every agentic action should be attributable to a human being. Audit logs should be stored somewhere outside of the agent's own reach. Audit logging and observability could have prevented the Replit incident, and could have really helped out in catching the Copilot incident as it happened. Alerting on logs in real time, as opposed to burying them in loads of data, would have meant catching these incidents in a matter of minutes instead of months.
What you need to control is the infrastructure that your AI is running on, the environments that it is working inside. Jiang compares this to the difference between telling someone don't leave a room versus putting a lock on the door and actually using a key. Because infrastructure, not the model, is the problem, you have far more control over preventing bad things from happening. Simply telling people to stop using AI is not a viable answer — the genie is out of the bottle — so what we have to do is mitigate risk and harm to the best of our ability. The talk focuses on steps you can take right now, as soon as this week, to protect yourself and your company, not things to keep an eye out for down the line.
Use AI as a first-pass reviewer for code review rather than having humans do every single review, and have humans review only what remains after the AI's first pass — otherwise human reviewers become the queue. Even after AI review, apply additional approval criteria to fully approve a PR.
Make CI really quick and fast by removing expensive checks and offloading them to post-merge so repairs are more efficient, and speed up CI by parallelizing work, sharding, and caching.
To live independently and move on your own as you age, you must engage in human movement, and any neuromuscular dysfunction prevents that. The only way to preserve neuromuscular function or fight its loss with aging is to strength train; strength training is also described as the only exercise route for keeping the nervous system healthy and young.
Dr. Andy Galpin recommends ending sets about two reps short of failure, targeting roughly minus two 'reps in reserve' as a good working number.
Dr. Andy Galpin recommends the 3-5 concept for speed and power training: 3-5 days per week, 3-5 exercises, 3-5 reps per set, 3-5 sets, resting 3-5 minutes between sets.
Dr. Andy Galpin prescribes three to five sets per exercise with three to five minutes of rest between sets for strength training.
Steve Jamison recommends that heading into budget season, you bring cost per PR to the table, not just your token bill or the throughput bump. His principle: the bill tells you what you spent; cost per PR tells you whether it worked. Right now, for most companies, cost per PR says keep investing.
The 'keep investing' conclusion is scoped to most companies right now, based on the study data.
Reps should leave kickoff with their quarter plan, territory plan, account plans, and a clear understanding of their number and how to hit it.
Do the full fitness assessment battery once a year. Technically it could all be done in two days, but a three-day split is probably best. Designate a testing week — Galpin loves this at the beginning of the year or whenever you change your training. Just like the fitness battery, you should probably go to a physician and get full blood work once a year. Don't worry about giving up your exercise routine during testing week — you won't finish the week thinking you didn't do much work, and it will feel great. After a testing week, you'll have a very nice barometer of exactly where you need to change and prioritize your training for the next quarter, half, or year.
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Dr. Thompson endorses that even after a procedure like gastric bypass surgery or going on a GLP-1, you still need to fix the fundamentals that got you into the problem to begin with: start getting more fiber, have a better diet and try to avoid insulin spikes, and start moving and exercising. Endoscopic procedures, surgeries, and medicines will fail unless you address those underlying problems.
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Dr. Chris Thompson recommends keeping the microbiome healthy via fiber and fermented beverages, because microbiome-derived butyrate is needed to produce healthy enterocytes, tight junctions, and a healthy mucin layer.
Dr. Chris Thompson recommends treating high fructose corn syrup like alcohol, and notes that fructose is something to watch — but not if it's in fruit; even juices are processed fruit and can be problematic.
Before attempting de-extinction, you should know what caused the species to go extinct and understand the role the animal played in its ecosystem and whether that niche is still available, so you don't bring something back that immediately goes extinct again.
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